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KMID : 0355620180440020066
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2018 Volume.44 No. 2 p.66 ~ p.72
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Desmoplastic melanoma of the oral cavity: diagnostic pitfalls and clinical characteristics
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Min Seung-Ki
Jeong Joo-Hee
Ahn Kang-Min
Yoo Chong-Woo
Park Joo-Yong
Choi Sung-Weon
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Abstract
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Objectives: Desmoplastic melanoma of the oral cavity is an extremely rare condition that is often confused on initial diagnosis with non-melanotic benign lesion or spindle cell tumors. The purpose of this article was to raise awareness of the disease using a literature review.
Materials and Methods: We analyzed 19 desmoplastic melanoma cases reported in the literature and added our experience. Data on clinical, histopathology, treatment, and survival were retrieved and analyzed. Survival analysis was by the Kaplan-Meier method.
Results: Initial clinical and histopathological features were indistinctive, and a definite diagnosis of desmoplastic melanoma at initial assessment was possible in only 23.5% of cases. Among tests, immunohistochemical studies for S-100 and vimentin were all positive. The 5-year disease-free survival rate for oral desmoplastic melanoma was 0%, and the 5-year overall survival rate was 55.0%.
Conclusion: Oral desmoplastic melanoma has a high percentage of initial misdiagnosis and propensity for local recurrence. Thus, careful initial diagnosis and adequate surgery may result in improved overall survival.
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KEYWORD
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Oral desmoplastic melanoma, Diagnosis, Recurrence, Survival
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